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Pharmoxyl

Capsule

🧬 Amoxicillin Trihydrate 🏢 Pharmadesh Laboratories Ltd.
Generic Name Amoxicillin Trihydrate
Strength 250 mg
Manufacturer Pharmadesh Laboratories Ltd.
Unit Price Unit Price: ৳ 3.25 (100's pack: ৳ 325.00)
Unit Price: ৳ 3.25 (100's pack: ৳ 325.00) ✅ In Stock per unit · Bangladesh
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🔹 Indications

🔹 Pharmacology

Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.

🔹 Dosage & Administration

Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
  • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
  • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
  • Pneumonia: Recommended dose is 500-1000 mg three times daily.
  • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
  • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
  • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
  • In renal impairment: it may be necessary to reduce the total daily dosage.

🔹 Interaction

Concurrent use of Pharmoxyl and Probenecid may result in increased and prolonged blood levels of Pharmoxyl. Pharmoxyl may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

🔹 Contraindications

Amoxicillin is contraindicated in penicillin hypersensitive patients.

🔹 Side Effects

Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.

🔹 Pregnancy & Lactation

US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.

🔹 Precautions & Warnings

The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Pharmoxyl should be discontinued and appropriate therapy should be instituted.

🔹 Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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💡 Frequently Asked Questions

Pharmoxyl is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)...
Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections. Severe or recurrent pur...
Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.

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