The adult dose of Mannitol ranges from 50 to 100 gm by IV infusion. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 ml/hr. Total dosage, concentration and the rate of administration depends on fluid requirement, urinary output and the severity of the condition being treated
Renal insufficiency-
- Adults: 50 to 100 g of Mannitol administered at a rate adjusted to maintain a urine flow of at least 30 to 50 ml/hr.
- Children: 2 gm/kg or 60 gm/m2 of body surface area administered over a period of 2 to 6 hrs.
Cerebral edema, elevated intracranial pressure, elevated intraocular pressure, Glaucoma-
- Adults: 1.5 to 2 gm/kg administered over a period of 30 to 60 minutes.
- Children: 1 to 2 gm/kg body wt. or 30 to 60 gm/m2 of body surface area administered over a period of 30 to 60 mins.
Adjunctive therapy for removal of toxic substances-
- Adults: 50 to 200 g of Mannitol administered at a rate adjust to maintain a urine flow of at least 100 to 500 ml/hr.
- Children: 2 gm/kg or 60 gm/m2 of body surface area
For termination of pregnancy 50 gm of Mannitol (250 ml of Mannitol) is instilled into the amniotic cavity which induces abortion in a high proportion of pregnancies.
